Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease.

BACKGROUND: Previous studies have suggested using gamma cameras with cadmium-zinc-telluride (CZT) detectors to quantify myocardial blood flow (MBF) and flow reserve (MFR). In this study, we aimed to evaluate the feasibility and accuracy of MFR quantification using a CZT camera compared to coronary angiography. METHODS: Forty-one participants referred for coronary angiography underwent a rest/stress one-day myocardial perfusion imaging protocol using a CZT gamma camera. Rest and stress dynamic phases were followed by acquisition of traditional perfusion images and time-activity curves were generated. Angiographic and perfusion results were compared to MFR. RESULTS: Patients with abnormal perfusion presented reduced MFR (2.01 [1.48-2.77] vs. 2.94 [2.38-3.64], P = 0.002), and reduced stress MBF. Patients with high-risk CAD had lower global MFR compared to patients without obstructive disease (1.99 [1.22-2.84] vs. 2.89 [2.22-3.58], P = 0.026). Obstructed vessels showed lower regional MFR when compared to non-obstructed (1.81 [1.19-2.67] vs. 2.75 [2.13-3.42], P < 0.001). A regional MFR of 2.2 provided a sensitivity of 63.2% and specificity of 74.1% to identify an obstructive lesion in the corresponding artery. CONCLUSION: In patients undergoing invasive coronary angiography for the evaluation of CAD, quantifying MBF and MFR in a CZT gamma camera is feasible and reflects underlying disease. In these patients, reduced regional MFR suggests the presence of obstructive lesion(s).

Angioplastia renal transluminal percutânea no tratamento da hipertensäo renovascular / Percutaneous Transluminal Renal Angioplasty for Treatment of Renovascular Hypertension

Objetivo - Avaliar o efeito da angioplastia renal transluminal percutânea (ARTP) no tratamento da hipertensäo renovascular. Métodos - Foram avaliados 23 pacientes com estenose da artéria renal e hipertensäo arterial submetidos à tentativa de ARTP. Onze indivíduos eram do sexo masculino e 12 do feminino com idades que variaram de 10 a 78 anos (45,8 ñ 17,41). Vinte Lesöes eram ateroscleróticas, 7 por displasia fibromuscular e 1 por arterite de Takayasu. Em 3 casos a dilataçäo foi bilateral e em 2 foi repetida por reestenose. Dois pacientes apresentavam insuficiencia renal aguda por estenose crítica das artérias renais. Resultados - Obteve-se sucesso técnico em 21 dos 25 procedimentos. Após 20 dilataçöes satisfatórias seguiu-se o sucesso clínico em 17(100// das lesöes por displasia fibromuscular e 77// das ateroscleróticas). A reduçäo da pressäo arterial diastólica após a ARTP foi estatisticamente significante (p<0,001). Nos dois casos de insuficiência renal aguda houve normalizaçäo da funçäo renal com a angioplastia. Ocorreram 2 complicaçöes e nenhum óbito foi relacionado ao procedimento. Conclusäo - O método foi eficaz e seguro no tratamento da hipertensäo renovascular no acompanhamento a curto prazo. Foi possível reverter a insuficiência renal aguda com a ARTP em 2 pacientes

Purpose - To analyze the effect of percutaneous transluminal renal angioplasty (PTRA) in renovascular hypertension. Methods - Twenty-three patients with renal artery stenosis and arterial hypertension underwent PTRA. There were 11 male an 12 female, 19 to 78 years old (45.8±17.41). In 20 lesions the diagnosis was atherosclerosis, in 7 fibromuscular dysplasia and in 1 Takayasu artheritis. Three patients underwent bilateral dilatation and 2 patients repeated the procedure due to reestenosis. Two patients presented with acute renal failure and severe bilateral renal artery stenosis. Results - There were 21 technical success in 25 procedures. After 20 satisfatory dilatations, clinical success followed in 17 (100% of cases of fibromascular dysplasia cases and 77% of atherosclerosis. The fall in diastolic arterial pressure after PTRA was statistical significant (p<0.001). In two cases acute renal failure the renal function became normal after angioplasty. There were 2 complications and no death attributed to PTRA. Conclusion - The method was effective and safe in the management of renovascular hypertension during the short-term follow-up. It was possible in two cases of acute renal failure to normalize renal function

Angioplastia ilíaca e enxerto fêmoro-femoral / Iliac percutaneous transluminal angioplasty and femoro-femoral by-pass

Os autores apresentam um caso de angioplastia transluminal percutânea em artéria ilíaca de um paciente com alto risco cirúrgico para o "by-pass" aorta-bifemoral. Neste paciente, a artéria ilíaca mais comprometida näo apresentava características angiográficas favoráveis para o procedimento em questäo. Com a dilataçäo do vaso contra-lateral foi possível evitar uma cirurgia de grande porte e realizar outra de menor risco operatório